Nintedanib Impurity 180 CAS 2117628-65-4 (free base)
| CAS No. | 2117628-65-4 (free base) |
| Molecular Formula | C14H22N4O |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Nintedanib Impurity 180 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 298.81 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Nintedanib Impurity 180 (CAS 2117628-65-4 (free base), C14H22N4OHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Nintedanib Impurity 180 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H22N4O HCl |
| Molecular Weight | 298.81 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Nintedanib Standards
- Nintedanib Impurity 158 (CAS 1023942-14-4)
- Nintedanib Impurity 9 (CAS 1038972-16-5)
- Nintedanib Impurity 156 (CAS 1040320-04-4)
- Nintedanib Impurity 19 (CAS 1125-88-8)
- Nintedanib Impurity 6 (CAS 1139453-98-7)
- Nintedanib Impurity N24 (CAS 1139455-52-9)
- Nintedanib Impurity N10 (CAS 1139457-10-5)
- Nintedanib Impurity N8 (CAS 1139458-48-2)
Recommended Standards
- Buspirone impurity 28 (CAS CATO-C4X-125828)
- Tedizolid impurity N2 (CAS 1195781-15-7)
- Suvorexant Impurity 51 (CAS CATO-C4X-181251)
- 6-Fluoro-4-nitropyridine-2-sulfonyl chloride (CAS 1393547-25-5)
- 1-(Tetrahydrofuran-2-carbonyl)azetidine-3-carboxylic acid (CAS 1339405-12-7)
- 2-Methyl-N-(1-(pyridin-2-yl)ethyl)prop-2-en-1-amine (CAS 1249163-08-3)
- 1-[(4-Hydrazinylphenyl)methyl]-1H-1,2,4-triazole (CAS 144035-22-3)
- 2-Chloro-3,5-diiodopyridin-4-amine (CAS 1171919-00-8)
- 2-Amino-5-bromo-N-cyclopropylnicotinamide (CAS 781642-04-4)
- Cholecystokinin Octapeptide (1-3) (desulfated) H-Asp-Tyr-Met-OH (CAS 121880-94-2)
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